Heat, moisture and friction are generally the cause of blisters. Blisters can also form from fungal infections, allergic reactions, and burns.
Proper care of blisters should involve draining their fluid but leaving their "skin" intact. Protect with a non-stick bandage with mild compression. Skin sprays and adhesive gel pads, as well as special socks, help minimize friction.
You can prevent blisters by breaking new shoes in before wearing them for extensive periods of time. Alternate your shoes so that you do not wear the same pair everyday. Also, wearing band-aids in likely blister spots can prevent them from occurring.
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